Malignant Mesothelioma

Malignant Mesothelioma is a rare growth of mesothelial cells form the lining layers of the viscera; strongly associated with asbestos exposure.

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Mesothelioma can occur at any mesothelial layer for example the peritoneum or pericardium; The pleural layer is by the far the most commonly affected, giving rise to malignant pleural mesothelioma.

The subtypes of asbestos strongly associated with malignant mesothelioma are the amosite and crocidolite asbestos.

Etiology

Malignant mesothelioma is primarily linked to asbestos exposure, with some suggesting that asbestos inhalation causes repeated pleural inflammation, interference with mitosis, activation of proto-oncogenes, and free radical production.

Other reports indicate associations with ionizing radiation, such as mantle radiation for Hodgkin lymphoma, or a germline mutation of BRCA 1 Associated Protein (BAP1).

Smoking and alcohol is directly linked with malignant pleural mesothelioma.

Pathophysiology

The three types of mesothelioma are epithelioid, sarcomatoid, and mixed.

The epithelioid type is associated with better outcomes. The tumor is often multifocal, forming multiple nodules starting with the parietal pleura. Spread occurs locally in the visceral pleura before extending to the chest wall, diaphragm, or mediastinum. Regional lymph node spread begins with the bronchopulmonary or hilar lymph nodes before moving to the carinal, internal mammary or peri diaphragmatic nodes.

The pattern of nodal metastases is different from that seen in lung cancer. With malignant pleural mesothelioma, there is a direct local invasion of the lymph nodes. Overall, the involvement of lymph nodes in malignant pleural mesothelioma is not common.

Histopathology of Malignant Mesothelioma :

Analysis of excised tissue usually reveals large nodules on the pleural surface. Three histological subtypes that are involved in malignant pleural mesothelioma include sarcomatous, mixed, and epithelial which has the best prognosis.

Symptoms and Physical :

Malignant pleural mesothelioma usually presents with an abdominal pain, chest pain and dyspnea. Dyspnea suggests the presence of pleural effusion, the most common initial finding, seen in about 90% of patients.

Nonspecific symptoms such as unintentional weight loss, appetite loss, cough, fatigue, and chest wall mass may also occur.

Diagnosis of Malignant Mesothelioma :

Diagnosis includes a thorax CT scan with intravenous contrast, a thoracoscopy pleural biopsy, and thoracentesis of pleural effusion, if present, with cytologic analysis.

Malignant pleural mesothelioma needs to be distinguished from other conditions. These conditions include benign pleural diseases as well as metastasis of other tumors such as lung adenocarcinoma or chest wall sarcoma.

A chest CT scan will show focal areas of pleural thickening, with a large invasive mass present in late-stage disease. PET scans may be used to screen for metastatic disease, while MRI and laparoscopy can be used to evaluate diaphragmatic invasion.

Megakaryocyte potentiating factor is used as a serum biomarker for malignant pleural mesothelioma.

Staging Malignant Mesothelioma

  • Stage I: A totally resected mass confined within the capsule of the parietal pleura. There is no lymphadenopathy.
  • Stage II: Has all the features of a stage I lesion, but the margins are positive after resection. There may be intrapleural lymphadenopathy.
  • Stage III: There is a local invasion of the mass into the mediastinum, pericardium, chest wall or peritoneum. Lymphadenopathy is common.
  • Stage IV: The presence of distant metastatic disease.

Differential Diagnosis

The differential diagnosis for malignant pleural mesothelioma includes:

  • Non-small cell lung cancer
  • Small cell lung cancer
  • Drug-induced lung complications
  • Benign pleural mass
  • Lung infection
  • Lung fibrosis

Allopathic treatment for Management Malignant Mesothelioma

Using National Comprehensive Cancer Network Guidelines, treatment depends upon tumor staging for the feasibility of surgical resection with Stage III-IV malignant pleural mesothelioma being considered unrespectable. Ultimately less than a third of patients are candidates for definitive resection. It is recommended that mesothelioma be treated by a multidisciplinary team at a high volume Homeopathic center.

For different types of cancers and mesotheliomas treatment click the following links:

Homeopathic treatment for malignant Mesothelioma

Phosphorus, Calceria carb, Sulphur, and Arsenicum Album are top grade Homeopathic remedies for Mesothelioma. They help in particular during the chronic stage of the disease, .

Phosphorus

Phosphorus irritates, inflames and degenerates mucous membranes, irritates and inflames serous membranes, Thirst for cold water especial indication, fatty degeneration of blood vessels and every tissue and organ, Tall, slender persons, narrow chested, with thin, transparent skin, weakened by loss of animal fluids, shooting pains, etc. Polycythemia. Blood extravasations; fatty degenerations, cirrhosis, caries,  Inflammation of the respiratory tract, Hoarseness; worse evenings. Larynx very painful. Clergyman’s sore throat; violent tickling in larynx while speaking. Aphonia, worse evenings, with rawness.

Cannot talk on account of pain in larynx. Cough from tickling in throat; worse, cold air, reading, laughing, talking, from going from warm room into cold air. Sweetish taste while coughing. Hard, dry, tight, racking cough. Congestion of lungs. Burning pains, heat and oppression of chest. Tightness across chest; great weight on chest. Sharp stitches in chest; respiration quickened, oppressed. Much heat in chest. Pneumonia, with oppression; worse, lying on left side. Whole body trembles with cough. Sputa rusty, blood-colored, or purulent.

Tuberculosis in tall, rapidly-growing young people {Do not give it too low or too frequently here, it may but hasten the destructive degeneration of tubercular masses. Repeated hemoptysis (Acal)}.

Pain in throat on coughing. Nervous coughs provoked by strong odors, entrance of a stranger; worse in the presence of strangers; worse lying upon left side.

 Calceria Carb

Swelling of tonsils and submaxillary glands; stitches on swallowing. Hawking-up of mucus, Profuse sweat in head and all over the body, Exhausted easily on exertion . Difficult swallowing. Goiter. Parotid fistula.

Tickling cough troublesome at night, dry and free expectoration in morning, Expectoration only during the day; thick, yellow, sour mucus. Bloody expectoration; with sour sensation in chest. Suffocating spells; tightness, burning and soreness in chest; worse going upstairs or slightest ascent, must sit down. Sharp pains in chest from before backwards. Chest very sensitive to touch, percussion, or pressure. Longing for fresh air. Scanty, salty expectoration (Lycopodium Clavatum).
Arsenicum album
Fear of death with a thirst for small quantities of water, Unable to lie down; fears suffocation. Air-passages constricted. Burning in chest. Suffocative catarrh. Cough worse after midnight; worse lying on back. Expectoration scanty, frothy. Darting pain through upper third of right lung. Wheezing respiration. Haemoptysis with pain between shoulders; burning heat all over. Cough dry, as from sulphur fumes; after drinking.
Mercurius Solubilis
Soreness from fauces to sternum. Cannot lie on right side (Left side, Lycop). Cough, with yellow mucopurulent expectoration. Paroxysms of two; worse, night, and from warmth of bed. Catarrh, with chilliness; dread of air. Stitches from lower lobe of right lung to back. Whooping-cough with nosebleed (Arnica) Cough worse, tobacco smoke.
THUJA OCCIDENTALIS
Dry, hacking cough in afternoon, with pain in pit of stomach. Stitches in chest; worse, cold drinks. Asthma in children (Nat sulph). Papilloma of larynx. Chronic laryngitis,  effectively stimulate cell-mediated immune system and decrease proinflammatory cytokines (Dr. qaisar Ahmed MD, DHMS).

Cannabis sativa (ultra diluted)

Patient can only breathe in standing position, Oppressed breathing, as from a weight on the chest, with wheezing, rattling breathing, sometimes with Loss of voice. Cough – dry, or with green, viscid sputum. Lungs Inflammation with stitches low downward, or with inflammation of the heart, or with vomiting of bile.

Violent palpitation of the heart/ Tachycardia, feels shocks and beats in the region of the heart.

Pain in the back, arresting the breathing.

DIGITALIS PURPUREA (ultra diluted)

Comes into play in all diseases where the heart is primarily involved, where the pulse is weak, irregular, intermittent, abnormally slow, and dropsy of external and internal parts. Weakness and dilatation of the myocardium. Its greatest indication is in failure of compensation and especially when auricular fibrillation has set in. Slow pulse in recumbent posture, but irregular and dicrotic on sitting up. Auricular flutter and fibrillation especially when subsequent to rheumatic fever. Heart block, very slow pulse. Other symptoms of organic heart disease, such as great weakness and sinking of strength, faintness, coldness of skin, and irregular respiration; cardiac irritability and ocular troubles after tobacco; jaundice from induration and hypertrophy of the liver, frequently call for Digitalis. Jaundice with heart disease. Faint, as if dying. Bluish appearance of face. Cardiac muscular failure when asystole is present. Stimulates the heart’s muscles, increases force of systole, increases length. Prostration from slight exertion. Collapse.

GRAPHITES (ultra diluted)
In my (Dr Qaisar Ahmed MD, DHMS)  experiences graphites works in many kind of cancers especially if patient is/was with contact of chemicals, acids, cement and smoke (factory etc).
CONIUM MACULATUM (ultra diluted)
This medicine is a deep, long acting antipsoric, establishing a state of disorder in the economy that is so far reaching and so long lasting that it disturbs almost all the tissues of the body. The complaints are brought on from taking cold, and the glands become affected all over the body. From every little cold the glands become hard and sore. Infiltration in deep-seated diseases in the region of ulcers and in the region of inflamed parts. Abscess surrounded by lumps and nodules, malignant affections of glands, because it takes hold of glands from the beginning and infiltrates, and they gradually grow to a stony hardness; like scirrhous, liver becomes indurated, sluggish, enlarged, paralysis of the oesophagus,  cancer.
NATRIUM SULPHURICUM (ultra diluted)

Duodenal catarrh; hepatitis; icterus and vomiting of bile; liver sore to touch, with sharp, stitching pains, Burning in abdomen and anus, yellow, watery stools, Loose morning stools.

CARCINOSINUM (ultra diluted)

It is claimed the Calcinosis acts favorably and modifies all cases in which either a history of carcinoma can be elicited, or symptoms of the disease itself exist; Carcinoma of the mammary glands with great pain and induration of glands.

P.S : Bryonia, China, Hepar Sulphuricum and Pulsatilla are Homeopathic medicines especially useful in the acute stage of Mesothelioma.

P. S : This article is only for doctors having good knowledge about Homeopathy and allopathy,  for learning purpose(s).

For proper consultation and treatment, please visit our clinic.

Location, address and contact numbers are given below.

NoN of above mentioned medicine(s) is/are not the full/complete treatment, but just hints for treatment; every patient has his own constitutional medicine along with these mentioned above.

To book an appointment or order medicine by courier, please send your details at WhatsApp– +923119884588

Raynaud's Phenomenon-Dr-Qaisar Ahmed-dixe-cosmeticsDr. Sayyad Qaisar Ahmed (MD {Ukraine}, DHMS) ; senior research officer Dnepropetrovsk state medical academy Ukraine; is a leading Homeopathic physician practicing in Al-Haytham clinic, Umer Farooq Chowk Risalpur Sadder (0923631023, 03119884588), K.P.K, Pakistan.

Find more about Dr. Sayyad Qaisar Ahmed at :

https://www.youtube.com/Dr Qaisar Ahmed

https://www.facebook.com/dr.qaisar.dixecosmetics

https://www.dixecosmetics.com

By Dr. Qaisar Ahmed. MD, DHMS.

Brief Profile Dr Qaisar Ahmed is a distinguished Physician & Chief Consultant at Al-Haytham Clinic, Risalpur. He is highly knowledgeable, experienced and capable professional who regularly contributes to various publications and runs a widely read specialized blog on health issues. Dr Qaisar Ahmed is one of the most sought after speakers at conferences and seminars on health and well being. Dr Qaisar Ahmed has a strong academic and professional background. Studied Masters in Medicines and surgery, Abdominal Surgeries, Oncological surgeries, Gastroenterologist, Senior research officer in Dnepropetrovsk state medical academy Ukraine; DHMS in Sarhad Medical college, Nowshera and is a registered Homeopathic practitioner (No. 164093) from The National Council of Homeopathy, Islamabad; Islamic Jurisprudence (Sharyat Law) from Allama Iqbal University, Islamabad. At the Dnipropetrovsk state medical Academy, Ukraine, Dr Qaisar Ahmed also attended many international seminars and workshops in the UK, Europe, Russia and UAE. Dr Qaisar Ahmed widely traveled the world and during his visits to Norway, Sweden and France, he learnt from acclaimed homeopathic practitioners and writers. At his registered establishment with the K.P.K Healthcare Commission Dr Qaisar Ahmed treats his patients as per international standards of homeopathy. He takes all kinds of chronic cases, though his main areas of focus include Cardiac diseases, Hypertension, Cholesterol, Asthma and other respiratory diseases, allergies and infection, Renal/urinary tract stones and diseases, Gastroenterology especially Gallbladder stones, haemorrhoids, Gastric ulcers, Crohn's disease, Eye diseases, Eyesight and cataracts, Sciatica, Rheumatoid and osteoArthritis, Gout, Varicose, Paralysis, Skin diseases and Unwanted facial Hairs, male/Female infertility, PCOS and menstrual diseases, Thyroid diseases. He runs a state of the art online homeopathy course “HOMEOPATHY for HOME”. This is an orientation course for the Homeopathy Medical System, meant for new homeopathic practitioners, basic learners, patients, allopathic doctors, nurses, alternative medicine practitioners, and students aspiring for a career in homeopathy. Dr Qaisar Ahmed belongs to the progeny of a noble Sayad (generation of Hazrat Mulk Shah Sahib - Sargodha who is the real son of Hazrat Hassan R.A) family of Risalpur, Khyber Pakhtunkhwa. His father Dr Inzar Gull is a distinguished Homeopathic doctor with deep insight into religion, pedagogy, oratory, faith healing and traditional medicines. Dr Qaisar Ahmed's inspiration for learning religion, its laws came from his father. He happily lives with his two wives and three children in Risalpur at Inzar Gull street, House# one. Location: Al-Haytham clinic, Umer Farooq Chowk Risalpur Sadder. K.P.K, Pakistan. Contacts: 0923631023, 03119884588, 03059820900. Find more about Dr Sayed Qaisar Ahmed at : https://www.youtube.com/Dr Qaisar Ahmed https://www.facebook.com/dr.qaisar.dixecosmetics

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