Noonan syndrome is a genetic disorder that affects many areas of the body and may cause short stature, distinctive facial features, heart abnormalities, bleeding abnormalities, scoliosis, infertility in males, lymphedema, and intellectual disability.
Thank you for reading this post, don't forget to subscribe!Noonan syndrome is inherited as an autosomal dominant disease (the abnormal gene is on a non-sex chromosome and requires just one of two inherited genes to be abnormal), which means one copy of the altered gene in each cell is sufficient to cause the disorder.
In some cases, an affected person inherits the mutation from one affected parent. Other cases result from new mutations in the gene and occur in people with no history of the disorder in their family.
Signs and symptoms
Patients with Noonan syndrome have distinctive facial features such as a deep groove in the area
between the nose and mouth (philtrum), widely spaced eyes that are usually pale blue or blue-green in color, and low-set ears that are rotated backward. Affected individuals may have a high arch in the roof of the mouth (high-arched palate), poor alignment of the teeth, and a small lower jaw (micrognathia). Many children with Noonan syndrome have a short neck and both children and adults may have excess neck skin (also called webbing) and a low hairline at the back of the neck.
Approximately 50 to 70 percent of individuals with Noonan syndrome have short stature. At birth, they are usually of normal length and weight, but growth slows over time. Abnormal levels of growth hormone may contribute to the slow growth.
Individuals with Noonan syndrome often have either a sunken chest (pectus excavatum) or a protruding chest (pectus carinatum). Some affected people may also have an abnormal side-to-side curvature of the spine (scoliosis).
Most people with Noonan syndrome have a heart defect. The most common heart defect is pulmonary valve stenosis. Some affected individuals have hypertrophic cardiomyopathy, which is a thickening of the heart muscle that forces the heart to work harder to pump blood.
A variety of bleeding disorders have been associated with Noonan syndrome. Some people may have excessive bruising, nosebleeds, or prolonged bleeding following injury or surgery. Women with a bleeding disorder typically have excessive bleeding during menstruation (menorrhagia) or childbirth.
Adolescent males with Noonan syndrome typically experience delayed puberty. Affected individuals go through puberty starting at age 13 or 14 and have a reduced pubertal growth spurt. Most males with Noonan syndrome have undescended testicles (cryptorchidism), which may be related to delayed puberty or to infertility later in life. Females with Noonan syndrome typically have normal puberty and fertility.
Noonan syndrome can cause a variety of other signs and symptoms. Most children diagnosed with Noonan syndrome have normal intelligence, but a small percentage has special educational needs, and some have intellectual disability. Some affected individuals have vision or hearing problems. Infants with Noonan syndrome may be born with puffy hands and feet caused by a buildup of fluid (lymphedema), which can go away on its own. Affected infants may also have feeding problems, which typically get better by age 1 or 2. Older individuals can also develop lymphedema, usually in the ankles and lower legs.
Diagnosis
Noonan syndrome is a common inherited disorder of cell growth affecting both males and females and characterized by atypical facial features, short stature, heart defects, bleeding problems, chest wall abnormalities, and other signs and symptoms.
What genes are related to Noonan syndrome?
Mutations in the PTPN11, SOS1, RAF1, KRAS, NRAS and BRAF genes cause Noonan syndrome.
Most cases of Noonan syndrome result from mutations in one of three genes, PTPN11, SOS1, or RAF1. PTPN11 gene mutations account for approximately 50 percent of all cases of Noonan syndrome. SOS1 gene mutations account for 10 to 15 percent and RAF1 gene mutations account for 5 to 10 percent of Noonan syndrome cases. About 2 percent of people with Noonan syndrome have mutations in the KRAS gene and usually have a more severe or atypical form of the disorder. It is not known how many cases are caused by mutations in the BRAF or NRAS genes, but it is likely a very small proportion. The cause of Noonan syndrome in the remaining 20 percent of people with this disorder is unknown.
The PTPN11, SOS1, RAF1, KRAS, NRAS and BRAF genes all provide instructions for making proteins that are important in signaling pathways needed for the proper formation of several types of tissue during development. These proteins also play roles in cell division, cell movement, and cell differentiation (the process by which cells mature to carry out specific functions). Mutations in any of the genes listed above cause the resulting protein to be continuously active, rather than switching on and off in response to cell signals. This constant activation disrupts the regulation of systems that control cell growth and division, leading to the characteristic features of Noonan syndrome.
Other names use for Noonan syndrome
- familial Turner syndrome
- Female Pseudo-Turner Syndrome
- Male Turner Syndrome
- Noonan-Ehmke syndrome
- pseudo-Ullrich-Turner syndrome
- Turner-like syndrome
- Turner’s phenotype, karyotype normal
- Turner syndrome in female with X chromosome
- Ullrich-Noonan syndrome.
Homeopathic Medicines for Hormone Imbalance
In my (Dr Qaisar Ahmed MD, DHMS, Isl. Juri) opinion, any genetic disease is not a disease or disorder itself but it is the result of mother’s malnutrition during her pregnancy; or use of too much allopathic drugs and/or supplements.
Here are very few Homeopathic medicines for Noonan syndrome:
Helonias
Albuminuria. Amenorrhoea. Anaemia. Breasts affections. Chlorosis. Debility. Diabetes. Dysmenorrhoea. Impotence. Kidneys, pains in. Leucorrhoea. Lochia, prolonged. Menopause. Menorrhagia. Metrorrhagia. Pruritus vulvae. Rheumatism. Splenalgia. Sterility. Uterus affections.
Pulsatilla Pratensis
Acne. Amaurosis. Amenorrhoea. Anaemia. Appetite, depraved. Bladder catarrh. Blepharospasm.
Breasts, pain behind. Bronchitis. Cataract. Catarrh. Chaps. Chest, pains in. Chilblains. Clavus. Cold. Cough. Diarrhoea; of phthisis. Distension. Dysmenia. Dyspepsia. Earache. Epilepsy. Epistaxis. Eyes lacrimal sac inflammation; granular ophthalmia. Fear. Feet, soles painful. Foetus mal-position. Freckles. Gonorrhoea. Gout. Haemorrhoids. Hands, pains in. Heart, palpitation of. Heartburn. Hydrocele; congenital. Hysteria. Intermittent fever. Joints synovitis. Labour spurious pains. Lactation disorders. Leucorrhoea. Measles. Menstruation, abnormal; vicarious. Moles. Mumps. Neuralgia. Nymphomania. Ovaries, Pain in; inflammation. Phlegmasia alba dolens. Pregnancy; bladder trouble; sickness; heartburn of; diarrhoea. Priapism. Prostate inflammation. Prostatorrhoea. Puerperal convulsions. Puerperal fever. Puerperal mania. Retained placenta. Rheumatism; gonorrhoeal. Side, pain in. Smell, illusions. Spine, curvature. Stye. Synovitis. Tapeworm. Taste: depraved; lost. Tongue, coated. Toothache. Urine incontinence. Uterus inflammation; prolapse. Veins inflammation; varicose. Whitlow.
Lilium Tigrinum
Angina pectoris. Asthenopia. Astigmatism. Dementia. Diarrhoea. Dysentery. Eyes affections. Fibroma. Heart affections; Palpitation. Hysteria. Ovaries affections. Dropsy. Pruritus vulvae. Spinal irritation. Urination, too frequent. Uterus affections; uterine displacements; subinvolution.
Aletris Farinosa
Abortion. Anaemia. Colic. Constipation. Convulsions. Debility. Dysmenorrhoea. Dysuria. Endometritis. Fever. Haemorrhoids. Hysteric colic. Indigestion. Leucorrhoea. Menorrhagia. Myalgia. Pregnancy vomiting. Sterility. Uterine pain and prolapse.
Pulsatilla
Most effective Homeopathic medicines for hormone imbalance leading to PCOS are Pulsatilla and Sepia.
Pulsatilla should be advised if periods are irregular, suppressed, scanty and very painful. Acne from hormonal or menstrual irregularities may appear. Labour pains, Spasmodic pains, hysterical spasms; Suppression of menses
Senecio Aureus
Amenorrhoea. Ascites. Coryza. Cough. Dropsy. Dysmenorrhoea. Dysuria. Epistaxis. Fainting. Gleet. Gonorrhoea. Haemorrhages. Home-sickness. Hysteria. Kidneys, inflammation of. Lumbago. Mania. Menorrhagia. Menstruation, delayed; early, and profuse; obstructed; vicarious. Nails, brittle. Nervousness. Neurasthenia. Phthisis. Prostatitis. Puerperal mania. Renal colic. Sciatica. Spermatic cord, pain in. Wounds.
Stannum
Anaemia. Asthma. Bronchitis. Chilblains. Colic. Consumption. Convulsions. Cramps. Debility. Dentition. Diaphragm, pains in. Dyspepsia. Ears, ring-holes, ulceration of. Epilepsy. Epistaxis. Gastralgia. Haematemesis. Haemoptysis. Headache. Hectic fever. Hemiplegia. Hypochondriasis. Hysteria. Lachrymal fistula. Lacrimal sac, suppuration of. Milk, altered. Nails, splitting. Neuralgia. Neurasthenia. Opisthotonos. Paralysis. Phthisis pituitosa. Ptosis. Sleeplessness. Styes. Tapeworm. Trachea, affections of. Uterus, prolapse of. Vagina, prolapse of. Worms.
Sepia
Amenorrhoea. Anus, pressure of. Apoplexy. Appetite, depraved. Ascarides. Baldness. Bladder, irritable. Cancer. Change of life. Chloasma. Chorea. Condylomata. Cystitis. Dandruff. Dysmenorrhoea. Dyspepsia. Eczema. Epistaxis. Eyes affections. Face, yellow. Freckles. Gleet. Gonorrhoea. Gravel. Herpes; circinatus. Hysteria. Irritation. Jaundice. Leucorrhoea. Liver-spots. Liver, torpid. Menstruation, disordered. Mind, affections of. Nails, pains under. Neuralgia. Nose, inflamed; swollen. Ozaena. Phimosis. Pityriasis versicolor. Pleurisy. Pregnancy disorders; vomiting. Pruritus. Psoriasis. Ptosis. Pylorus induration. Quinsy. Rectum cancer; fissure. Ringworm. Sacrum, pain in. Sciatica. Seborrhoea. Sense of smell too acute; disordered. Spermatorrhoea. Stye. Toothache. Urine incontinence. Uterus bearing down. Varicose veins. Warts. Whooping-cough.
Lachesis
Albuminuria. Alcoholism. Amblyopia. Aneurysm. Apoplexy. Appendicitis. Asthenopia. Asthma. Atheroma. Bedsores. Boils. Bubo. Caecum, inflammation of. Carbuncle. Catalepsy. Chancre. Menopause. Chilblains. Ciliary neuralgia. Cough. Cyanosis. Delirium tremens. Diphtheria. Dog-bite. Dropsy. Dyspepsia. Ears polypus; wax in; noises in. Enteric fever. Epilepsy. Erysipelas. Eyes affections; haemorrhage into. Fainting. Fistula lachrymalis. Flatulence. Fungus haematodes. Gallstones. Gangrene. Glanders. Gums, bleeding of. Haemorrhages. Haemorrhoids. Hay fever. Headache. Heart affections. Heartburn. Hemiplegia. Hernia. Herpes facialis. Hoarseness. Hydrophobia. Hysteria. Injuries. Intermittent fever. Jaundice. Labour pains after. Laryngismus. Laryngitis. Leprosy. Liver affections. Locomotor ataxy. Malignant pustule. Measles. Meniere’s disease. Mercury effects. Mind affections. Morvan’s disease. Mouth, sore. Mumps. Neuralgia. Neurasthenia. Noises in ears. Nymphomania. Edema of lungs. Otorrhoea. Ovaries affections. Paralysis. Paraphimosis. Perityphlitis. Perspiration, bloody; absent. Phlegmasia alba dolens. Plague. Pneumonia. Puerperal fever and convulsions. Purpura. Pyaemia. Quinsy. Rabies. Scarlatina. Sciatica. Scurvy. Smallpox. Stings. Strangury. Syphilis. Throat, sore. Trachea, affections of. Traumatic fever. Tumours. Ulcers. Veins, varicose. Vertigo. Vicarious menstruation (nosebleed). Warts. Whitlow. Wounds.
Ignatia Amara
Abdomen, distended. Anger effects. Anus affections. Anxiety. Appetite, disordered. Back weakness. Catalepsy. Manopause. Chorea. Clavus. Convulsions. Croup. Debility. Dentition. Depression of Spirits. Diphtheria. Dysmenorrhoea. Epilepsy. Fainting. Fear effects. Flatulence; obstructed. Glands enlargement. Haemorrhoids. Headache. Heart affections. Hiccough. Hysteria. Hysterical-joint. Intermittent fever. Locomotor ataxy. Melancholia. Numbness. Esophagus. Paralysis. Phlyctenular ophthalmia. Proctalgia. Rectum, prolapse of. Rheumatic fever. Sciatica. Sensitiveness. Sinking. Sleep, disordered. Spinal irritation. Tenesmus. Throat, sore. Toothache. Tremors. Urine, abnormal. Vagina, spasm of. Voice, lost. Yawning.
Conium Maculatum
Asthma. Bladder inflammation. Breast affections; painful. Bronchitis. Bruises. Cancer. Cataract. Chorea. Cough. Depression of spirits. Diphtheritic paralysis. Dysmenia (membranous). Erysipelas. Eyes affections. Galactorrhoea. Herpes. Hypochondriasis. Jaundice. Liver, enlarged. Melancholia. Menstruation, disordered. Numbness. Ovaries affections. Paralysis; Landry’s. Peritonitis. Phthisis. Pregnancy, painful breasts during. Prostatitis. Ptoses. Scrofula. Spermatorrhoea. Sterility. Stomach, affections of. Testicles affections. Tetters. Trismus. Tumours. Ulcers. Vertigo. Vision, disordered. Wens.
Agnus Castus
Agalactia. Anus, excoriation and chaps of. Ascites. Dislocations, Gonorrhoea, secondary. Gouty joints. Gums, ulcerated. Impotence. Knees coldness. Leucorrhoea. Mouth, ulcers in. Rheumatic nodes. Spleen, swelling; induration. Sprains. Sterility. Testicles swelling; induration.
Caladium
Asthma. Dropsical swellings. Gleet. Impotence. Irritation. Nymphomania. Pruritus vaginae. Spermatorrhoea. Typhoid. Typhus. Worms.
Lycopodium
Abdomen, distended. Abortion. Albuminuria. Aneurysm. Angina pectoris. Aphasia. Asthma. Axilla – offensive perspiration. Biliousness. Borborygmi. Bright’s disease. Cancer. Cataract. Constipation. Consumption. Corns. Cough. Cramps. Cystitis. Debility. Diphtheria. Distension. Dropsies. Dysentery. Dysmenorrhoea. Dyspepsia. Ear, eczema behind. Eczema. Ephelis. Epistaxis. Epithelioma. Excoriation. Eye inflammation; polypus of canthus. Face eruption. Feet perspiring. Fibroma. Flatulence. Gallstone colic. Glands swelling. Goetre. Gout. Gravel. Haematuria. Haemorrhoids. Hair, falling out. Hands, chapped. Heartburn. Heart diseases. Hemiopia. Hernia. Hydropericardium. Hypochondriasis. Hysteria. Impotence. Influenza. Intermittents. Intertrigo. Irritation. Labour-pains, abnormal. Lip cancer. Liver derangement of. Liver-spots. Locomotor ataxy. Lungs affections. Menstruation disorders. Metrorrhagia. Naevus. Nymphomania. Otorrhoea. Panaritium. Paralysis. Paralysis agitans. Peritonitis. Phlegmasia dolens. Physometra. Plica polonica. Pneumonia. Polypus of eye; of ear; of nose. Proctalgia. Prostatitis. Pylorus affections. Quinsy. Renal colic. Rheumatism. Rhagades. Sciatica. Sleep, abnormal. Speech, disordered; stammering. Strains. Sunstroke. Taste abnormal. Throat sore. Tongue coated; cramp in. Typhoid fever. Urine abnormal. Varicosis. Warts. Water-brash. Whooping-cough. Worms. Yawning.
Acid Phosphoricum
Amblyopia. Asthma. Boils. Brain-fag. Bronchitis; capillary. Chancre. Chilblains. Cholera. Climacteric flushes and vertigo. Coccygodynia. Condylomata. Corns. Cough. Coxalgia. Debility. Diabetes. Diarrhoea. Dyspepsia. Emissions. Enteric fever. Enuresis. Feet, sore. Flatulence. Ganglion. Gout. Gravel. Hair, falling off. Headache. Hectic. Herpes. Hip-joint disease. Home-sickness. Impotence. Joints, scrofulous. Lactation defective. Levitation. Lienteria. Locomotor ataxy. Love, disappointed. Masturbation. Mental weakness. Mercurial syphilis. Navel, pains in. Neurasthenia. Nymphomania. Osteomyelitis. Perspiration, profuse. Phosphaturia. Physometra. Pimples. Pregnancy – diarrhoea; nausea. Prepuce – warts. Psoas abscess. Puerperal eclampsia. Purpura. Rheumatism. Sciatica. Scurvy. Self-abuse. Spermatorrhoea. Spinal caries. Sycosis Hahnemanni. Syphilis. Tetters. Typhus fever. Ulcers. Urine, phosphatic. Uterus, prolapse of. Varices. Vertigo. Warts. Wens. Worms.
Selenium
Alcoholism. Ankle, itching eruption about. Comedo. Constipation. Debility. Enuresis. Hair – falling out. Headache. Hoarseness. Impotence. Laryngitis, scrofulous; tubercular. Liver affections; rash over region of. Priapism. Prostatitis. Prostatorrhoea. Psoriasis palmaris. Reveries. Scabies. Scalp – eczema. Skin unhealthy. Spermatorrhoea. Stammering.
Calcarea Carbonica
Abdomen large. Acidity. Anaemia. Ankles weak. Appetite depraved. Beard sycosis. Bone disease. Brachial neuralgia. Breasts painful. Bronchial glands affections. Calculus. Caries. Cataract. Chilblains. Chorea. Cold. Consumption. Corpulency. Coryza. Cough. Coxalgia. Croup. Crusta lactea. Debility. Delirium tremens. Dentition. Diabetes. Diarrhoea. Dropsy. Dyspepsia. Ear affections. Epilepsy. Epulis. Eyes affections. Fever, intermittent. Fistula. Gallstones. Glandular swellings. Gleet. Goetre. Gonorrhoea. Gouty swellings. Headache. Hernia. Herpes. Hydrocephalus. Hypochondriasis. Hysteria. Impotence. Joints affections. Lactation – defective. Leucocythaemia. Leucorrhoea. Lupus. Masturbation. Melancholia. Menstruation disorders. Milk-fever. Miller’s phthisis. Miscarriage. Molluscum contagiosum. Naevus. Nervous fever. Neuralgia. Night terrors. Paralysis. Parotitis. Peritonitis. Perspiration. Plethora. Polypus. Pregnancy. Prosopalgia. Psoriasis palmaris. Ranula. Renal colic. Rhagades. Rheumatism. Rickets. Ringworm. Sciatica. Scrofula. Skin affections. Sleep disorders. Sleeplessness. Smell disorder. Spinal affections. Stone-cutter’s phthisis. Strains. Sycosis. Sycosis menti. Tabes mesenterica. Tapeworm. Taste, disordered. Teeth carious. Toothache. Trachea affections. Tuberculosis. Tumours. Typhoid. Urticaria. Uterus affections. Varices. Vertigo. Walking late. Warts. Whitlow. Worms.
Iodum
Appetite disordered. Atrophy. Brain atrophy. Breasts affections. Cancer. Chilblains. Chyluria. Constipation. Consumption. Coryza. Cough. Croup. Debility. Diabetes. Diarrhoea. Diphtheria. Emaciation. Enteric fever. Galactorrhoea. Goetre Haemorrhoids. Headaches. Heart hypertrophy and affections. Hiccough. Hydrocephalus. Iritis. Jaundice. Joints affections. Lactation disordered. Laryngitis Leucorrhoea. Liver affections. Lymphatic swellings. Melancholia. Mollities ossium. Ovaries affections, dropsy. Ozaena. Prostate gland, enlarged. Rheumatic gout. Rheumatism. Salivation. Scars. Seborrhoea. Sterility. Syphilis. Tabes mesenterica. Throat affections. Uterus affections. Voice affections. Vomiting. Worms.
Natrum Muriaticum
Addison’s disease. Anaemia. Aphthae. Atrophy. Brain-fag. Catarrh. Chorea. Constipation. Cough. Cracks in the skin. Debility. Depression. Diabetes. Dyspareunia. Dropsy. Dyspepsia. Epilepsy. Erysipelas. Eyes affections. Eye-strain. Face complexion unhealthy. Gleet. Glossopharyngeal paralysis. Goetre. Gonorrhoea. Gout. Headache. Heart affections. Hemiopia. Hernia. Herpes. Herpes circinatus. Hiccough. Hodgkin’s disease. Hydroa. Hypochondriasis. Intermittent fever. Leucocythaemia. Leucorrhoea. Lips eruption. Lungs oedema. Menstruation disorders. Mouth inflammation. Nettle rash. Pediculosis. Ranula. Seborrhoea. Self-abuse. Somnambulism. Speech, embarrassed. Spermatorrhoea. Spinal irritation. Spleen enlarged. Sterility. Stomatitis. Sunstroke. Taste lost; disordered. Tongue, blistered; white coated; heavy. Trifacial-nerve paralysis. Ulcers. Varices. Vaginismus. Vertigo. Warts. Whooping-cough. Worms. Yawning.
P. S : This article is only for doctors having good knowledge about homeopathy, and for learning purpose(s).
NoN of above mentioned medicine(s) is/are not the full/complete treatment but just hints for treatment; every patient has his own constitutional medicine along with these mentioned above.
For consultation; Feel free to whatsapp us or visit our clinic.
P. S : This article is only for doctors having good knowledge about Homeopathy and allopathy, for learning purpose(s).
For proper consultation and treatment, please visit our clinic.
Location, address and contact numbers are given below.
NoN of above mentioned medicine(s) is/are the full/complete treatment, but just hints for treatment; every patient has his/her own constitutional medicine.
To order medicine by courier, please send your details at WhatsApp– +923119884588
Dr. Sayyad Qaisar Ahmed (MD {Ukraine}, DHMS), Abdominal Surgeries, Oncological surgeries, Gastroenterologist, Specialist Homeopathic Medicines.
Senior research officer at Dnepropetrovsk state medical academy Ukraine.
Location: Al-Haytham clinic, Umer Farooq Chowk Risalpur Sadder (0923631023, 03119884588), K.P.K, Pakistan.
Find more about Dr Sayed Qaisar Ahmed at :
https://www.youtube.com/Dr Qaisar Ahmed